Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 17/20 | 0.61 |
| ▸ | WNT1 | P04628 | 12/20 | 0.61 |
| ▸ | GSK3B | P49841 | 12/20 | 0.61 |
| ▸ | CLK2 | P49760 | 3/20 | 0.60 |
| ▸ | CLK3 | P49761 | 3/20 | 0.60 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20030376 | 0.82 | DYRK1A (0.59) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23916692 | 0.80 | DYRK1A (0.57) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048633 | 0.79 | DYRK1A (0.57) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048703 | 0.78 | DYRK1A (0.64) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL24219353 | 0.77 | GSK3B (0.56) | DYRK1AWNT1GSK3B | |
| SCHEMBL23916586 | 0.77 | DYRK1A (0.61) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL30003768 | 0.76 | DYRK1A (1.00) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL19517385 | 0.76 | DYRK1A (1.00) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23048901 | 0.75 | DYRK1A (0.59) | DYRK1AWNT1GSK3BCLK2CLK3 | |
| SCHEMBL23916189 | 0.75 | DYRK1A (0.72) | DYRK1AWNT1GSK3BCLK2CLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3892276-A1 | ISOQUINOLIN-3-YL CARBOXAMIDES AS WNT INHIBITORS | BioSplice Therapeutics, Inc. (US) | 2021-10-13 | — | — | EP | disclosed |