Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 13/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 12/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 12/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.57 |
| ▸ | PRKDC | P78527 | 12/20 | 0.57 |
| ▸ | ABL1 | P00519 | 11/20 | 0.57 |
| ▸ | EGFR | P00533 | 11/20 | 0.57 |
| ▸ | HCK | P08631 | 11/20 | 0.57 |
| ▸ | SRC | P12931 | 11/20 | 0.57 |
| ▸ | KDR | P35968 | 11/20 | 0.57 |
| ▸ | MTOR | P42345 | 11/20 | 0.57 |
| ▸ | EPHB4 | P54760 | 10/20 | 0.57 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.57 |
| ▸ | EIF2AK3 | Q9NZJ5 | 6/20 | 0.52 |
| ▸ | MET | P08581 | 1/20 | 0.49 |
| ▸ | AXL | P30530 | 1/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917414 | 0.85 | EIF2AK3 (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL20351783 | 0.85 | RIPK2 (0.61) | SRCEIF2AK3METAXL | |
| SCHEMBL23917434 | 0.81 | SRC (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL26110170 | 0.81 | AXL (0.63) | ABL1EGFRSRCKDREIF2AK3 | |
| SCHEMBL30582589 | 0.81 | AXL (0.63) | ABL1EGFRSRCKDREIF2AK3 | |
| SCHEMBL22434462 | 0.81 | EIF2AK3 (0.50) | EIF2AK3METAXL | |
| SCHEMBL20351797 | 0.80 | EIF2AK3 (0.48) | ABL1EGFRSRCKDREIF2AK3 | |
| SCHEMBL13020096 | 0.79 | SRC (0.69) | ABL1EGFRHCKSRCKDR | |
| SCHEMBL18874076 | 0.79 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGPRKDC | |
| SCHEMBL25285654 | 0.78 | NEK7 (0.56) | EIF2AK3METAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | PIK3CD 2/4885PIK3CA 6/4885PIK3CB 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.