Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 8/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 8/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.49 |
| ▸ | PRKDC | P78527 | 7/20 | 0.49 |
| ▸ | ABL1 | P00519 | 6/20 | 0.49 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | HCK | P08631 | 6/20 | 0.49 |
| ▸ | MTOR | P42345 | 6/20 | 0.49 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 5/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 4/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | JAK3 | P52333 | 4/20 | 0.49 |
| ▸ | BTK | Q06187 | 1/20 | 0.46 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23917279 | 0.81 | SRC (0.62) | SRCAURKAIKBKEAURKBPIK3CD | |
| SCHEMBL23917549 | 0.81 | SRC (0.59) | SRCAURKAIKBKEAURKBPIK3CD | |
| SCHEMBL16665792 | 0.79 | SRC (0.45) | SRCAURKAPIK3CDPIK3CAPIK3CB | |
| SCHEMBL16702105 | 0.79 | JAK3 (0.53) | SRCPIK3CDPIK3CGEGFRJAK2 | |
| SCHEMBL16701666 | 0.78 | PIK3CD (0.53) | SRCPIK3CDEGFRJAK2JAK3 | |
| SCHEMBL23917265 | 0.78 | PIK3CD (0.62) | SRCAURKAIKBKEAURKBPIK3CD | |
| SCHEMBL16701668 | 0.77 | BTK (0.48) | SRCPIK3CDPIK3CGPRKDCEGFR | |
| SCHEMBL16702110 | 0.77 | JAK3 (0.51) | SRCPIK3CDEGFRJAK2JAK3 | |
| SCHEMBL16701680 | 0.77 | PIK3CD (0.59) | SRCPIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL16655521 | 0.77 | PIK3CD (0.69) | SRCPIK3CDBTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | MEDIVATION TECHNOLOGIES, INC. (US) | 2021-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210317140-A1 | Heterocyclic Compounds and Methods of Use | BTK, PIK3CD, PIK3CB | SRC 92/4885AURKA 811/4885IKBKE 110/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.