Sugi Predict

Sugi Predict / Compounds / SCHEMBL23923655

SCHEMBL23923655

SCHEMBL23923655

Cc1cc(N2C[C@H]3CC[C@@H](C2)C3N)cnn1

nearest known ligand 0.41

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ PSEN1 P49768 2/20 0.41
▸ PSEN2 P49810 2/20 0.41
▸ APH1B Q8WW43 2/20 0.41
▸ NCSTN Q92542 2/20 0.41
▸ APH1A Q96BI3 2/20 0.41
▸ PSENEN Q9NZ42 2/20 0.41
▸ APP P05067 1/20 0.40
▸ CHRNB2 P17787 5/20 0.35
▸ CHRNB4 P30926 5/20 0.35
▸ CHRNA3 P32297 5/20 0.35
▸ CHRNA4 P43681 5/20 0.35
▸ HRH4 Q9H3N8 11/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28425546 1.00 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL22111574 1.00 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL23923652 1.00 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL23923654 1.00 PSEN1 (0.41) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL20609183 0.83 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL20609186 0.83 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL23902357 0.83 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL18971038 0.83 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL20031689 0.83 PSEN1 (0.39) PSEN1PSEN2APH1BNCSTNAPH1A
SCHEMBL21374330 0.82 APP (0.41) PSEN1PSEN2APH1BNCSTNAPH1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326758-A1 RICYCLIC HETEROARYL DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2025-10-23 — — US disclosed
US-12195470-B2 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma- secretase modulators for the treatment of alzheimer's disease HOFFMANN-LA ROCHE INC. (US) 2025-01-14 — — US disclosed
US-12084461-B2 Bicyclic heteroaryl derivatives HOFFMANN-LA ROCHE INC. (US) 2024-09-10 — — US disclosed
EP-4424370-A2 7-PHENOXY-N-(3-AZABICYCLO[3.2.1LOCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE F. Hoffmann-La Roche AG (CH) 2024-09-04 — — EP disclosed
EP-3894411-B1 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE HOFFMANN LA ROCHE (CH) 2024-06-19 — — EP disclosed
CN-117946116-A 6, 7-Dihydro-5H-pyrrolo [1,2-B ] [1,2,4] triazol-2-amine derivatives 豪夫迈·罗氏有限公司 2024-04-30 — — CN disclosed
CN-112566696-B Bicyclic heteroaryl derivatives 豪夫迈·罗氏有限公司 2024-01-16 — — CN disclosed
CN-113179641-B 6, 7-dihydro-5H-pyrrolo [1,2-B ] [1,2,4] triazol-2-amine derivatives 豪夫迈·罗氏有限公司 2024-01-02 — — CN disclosed
CN-111417636-B Triazolo-aza derivatives 豪夫迈·罗氏有限公司 2023-09-26 — — CN disclosed
US-11370802-B2 Triazolo-azepine derivatives HOFFMANN-LA ROCHE, INC. (US) 2022-06-28 — — US disclosed
US-11370802-B2 Triazolo-azepine derivatives HOFFMANN-LA ROCHE, INC. (US) 2022-06-28 — — US disclosed
US-20220056036-A1 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE HOFFMANN-LA ROCHE INC. (US) 2022-02-24 — — US disclosed
EP-3743428-B1 TRIAZOLO-AZEPINE DERIVATIVES HOFFMANN LA ROCHE (CH) 2022-01-19 — — EP disclosed
US-20210395270-A1 TRIAZOLO-AZEPINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2021-12-23 — — US disclosed
US-20210395270-A1 TRIAZOLO-AZEPINE DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2021-12-23 — — US disclosed
US-20210323980-A1 BICYCLIC HETEROARYL DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2021-10-21 — — US disclosed
US-20210323980-A1 BICYCLIC HETEROARYL DERIVATIVES HOFFMANN-LA ROCHE INC. (US) 2021-10-21 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12084461-B2 Bicyclic heteroaryl derivatives AR, CYP1B1, CYP1A1 PSEN1 2562/4885PSEN2 2218/4885APH1B 1072/4885
US-20210323980-A1 BICYCLIC HETEROARYL DERIVATIVES AR, CYP1B1, CYP1A1 PSEN1 2562/4885PSEN2 2218/4885APH1B 1072/4885
US-20210395270-A1 TRIAZOLO-AZEPINE DERIVATIVES BACE1, APP, BACE2 PSEN1 5/4885PSEN2 8/4885APH1B 6/4885
US-20220056036-A1 7-PHENOXY-N-(3-AZABICYCLO[3.2.1]OCTAN-8-YL)-6,7-DIHYDRO-5H-PYRROLO[1,2-B][1,2,4]TRIAZOL-2-AMINE DERIVATIVES AND RELATED COMPOUNDS AS GAMMA-SECRETASE MODULATORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE BACE1, PSEN1, APP PSEN1 2/4885PSEN2 4/4885APH1B 5/4885
US-12195470-B2 7-phenoxy-N-(3-azabicyclo[3.2.1]octan-8-yl-6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazol-2-amine derivatives and related compounds as gamma- secretase modulators for the treatment of alzheimer's disease BACE1, PSEN1, APP PSEN1 2/4885PSEN2 4/4885APH1B 6/4885
US-11370802-B2 Triazolo-azepine derivatives BACE1, APP, BACE2 PSEN1 5/4885PSEN2 8/4885APH1B 6/4885
US-20250326758-A1 RICYCLIC HETEROARYL DERIVATIVES AR, CYP1B1, CYP1A1 PSEN1 3060/4885PSEN2 2846/4885APH1B 899/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.