Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | CFTR | P13569 | 2/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23923978 | 1.00 | PTPN22 (0.72) | PTPN22NPC1RAB9AHSD17B10USP2 | |
| SCHEMBL23947534 | 0.92 | PTPN22 (0.61) | PTPN22HSD17B10USP2TP53ALOX15 | |
| SCHEMBL23947942 | 0.89 | PTPN22 (0.59) | PTPN22NPC1RAB9AHSD17B10USP2 | |
| SCHEMBL23951220 | 0.89 | PTPN22 (0.59) | PTPN22NPC1RAB9AHSD17B10USP2 | |
| SCHEMBL23947588 | 0.89 | PTPN22 (0.58) | PTPN22HSD17B10USP2TP53ALOX15 | |
| SCHEMBL23923885 | 0.84 | PTPN22 (1.00) | PTPN22KDM4ENR4A2CFTR | |
| SCHEMBL22885957 | 0.84 | PTPN22 (1.00) | PTPN22KDM4ENR4A2CFTR | |
| SCHEMBL23947391 | 0.84 | PTPN22 (1.00) | PTPN22KDM4ENR4A2CFTR | |
| SCHEMBL23947417 | 0.83 | PTPN22 (0.80) | PTPN22CFTRCTSLCTSBCTSS | |
| SCHEMBL23948060 | 0.82 | PTPN22 (0.79) | PTPN22CFTRCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118290333-A | Novel inhibitors of gonorrhoeae-specific tyrosine phosphatase (LYP) | 普渡研究基金会 | 2024-07-05 | — | — | CN | disclosed |
| CN-115461056-B | Inhibitors of Lebaba-specific tyrosine phosphatase (LYP) | 普渡研究基金会 | 2024-04-16 | — | — | CN | disclosed |
| US-11629130-B2 | Lymphoid-specific tyrosine phosphatase (LYP) inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2023-04-18 | — | — | US | disclosed |
| EP-4135711-A1 | NOVEL LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP) INHIBITORS | Purdue Research Foundation (US) | 2023-02-22 | — | — | EP | disclosed |
| WO-2021211191-A1 | NOVEL LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP) INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | WO | disclosed |
| WO-2021211191-A1 | NOVEL LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP) INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | US | disclosed |
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11629130-B2 | Lymphoid-specific tyrosine phosphatase (LYP) inhibitors | PTPN22, PTPN1, PTPRCAP | PTPN22 1/4885NPC1 4310/4885RAB9A 2365/4885 |
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PTPN22, PTPN1, PTPRCAP | PTPN22 1/4885NPC1 4352/4885RAB9A 2172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.