Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.38 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20524643 | 0.84 | HCAR2 (0.46) | HCAR2KDM5AKDM5B | |
| SCHEMBL20524651 | 0.82 | HCAR2 (0.38) | HCAR2KDM5AKDM5B | |
| SCHEMBL369544 | 0.82 | NPC1 (0.39) | HCAR2 | |
| Hydrochloric Acid SCHEMBL28435492 | 0.81 | HCAR2 (0.37) | HCAR2KDM5AKDM5B | |
| SCHEMBL25289020 | 0.78 | KMT2A (0.45) | — | |
| Sulfuric Acid SCHEMBL28426836 | 0.77 | HCAR2 (0.34) | HCAR2KDM5AKDM5B | |
| SCHEMBL16143800 | 0.74 | — | — | |
| SCHEMBL10665972 | 0.73 | GAA (0.40) | HCAR2 | |
| SCHEMBL15555947 | 0.72 | — | — | |
| SCHEMBL27804321 | 0.72 | SRD5A2 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021211922-A1 | SPIRO-SULFONIMIDAMIDE DERIVATIVES AS INHIBITORS OF MYELOID CELL LEUKEMIA-1 (MCL-1) PROTEIN | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2021-10-21 | — | — | WO | disclosed |