Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CKS1B | P61024 | 1/20 | 0.52 |
| ▸ | SKP1 | P63208 | 1/20 | 0.52 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.52 |
| ▸ | ACACB | O00763 | 9/20 | 0.48 |
| ▸ | ACACA | Q13085 | 9/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.47 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18940284 | 1.00 | CKS1B (0.52) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL18940311 | 0.86 | PTGER4 (0.43) | CKS1BSKP1SKP2ACACB | |
| SCHEMBL25081256 | 0.78 | CKS1B (0.55) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL25766607 | 0.78 | CKS1B (0.62) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL18940291 | 0.76 | SMO (0.42) | IRAK1 | |
| SCHEMBL21522618 | 0.76 | CHRM2 (0.53) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL27087870 | 0.76 | CKS1B (0.50) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL10230218 | 0.76 | CKS1B (0.59) | CKS1BSKP1SKP2ACACBACACA | |
| SCHEMBL25189130 | 0.76 | MEN1 (0.43) | CKS1BSKP1SKP2SUV39H2 | |
| SCHEMBL10230212 | 0.76 | CKS1B (0.59) | CKS1BSKP1SKP2ACACBACACA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082786-B1 | ANTIDIABETIC SUBSTITUTED HETEROARYL COMPOUNDS | MERCK SHARP & DOHME (US) | 2021-10-27 | — | — | EP | disclosed |