SCHEMBL23930403

SCHEMBL23930403

COC(=O)c1cc(C#N)c(Br)cc1C(F)(F)F

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 2/20 0.48
GAA P10253 1/20 0.45
SOS1 Q07889 1/20 0.44
CFTR P13569 3/20 0.43
KDM4E B2RXH2 3/20 0.41
MAPT P10636 2/20 0.41
LMNA P02545 1/20 0.41
RXFP1 Q9HBX9 1/20 0.41
HPGD P15428 2/20 0.40
ALDH1A1 P00352 3/20 0.39
CYP1A2 P05177 1/20 0.39
CYP3A4 P08684 1/20 0.39
CYP2D6 P10635 1/20 0.39
CYP2C9 P11712 1/20 0.39
CYP2C19 P33261 1/20 0.39
KMT2A Q03164 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
AR P10275 2/20 0.38
CRHBP P24387 1/20 0.38
CRHR2 Q13324 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22833375 0.89 NOTUM (0.48) NOTUMGAASOS1CFTRKDM4E
SCHEMBL23754117 0.84 GAA (0.46) NOTUMGAACFTRKDM4EMAPT
SCHEMBL23043990 0.83 GAA (0.53) GAASOS1KDM4EMAPTLMNA
SCHEMBL23930401 0.83 CFTR (0.56) NOTUMGAACFTRKDM4EMAPT
SCHEMBL2428349 0.80 CFTR (0.56) NOTUMGAASOS1CFTRKDM4E
SCHEMBL2426249 0.80 CFTR (0.52) NOTUMGAACFTRKDM4EMAPT
SCHEMBL19682922 0.78 GAA (0.44) NOTUMGAASOS1KDM4EMAPT
SCHEMBL20129680 0.77 GAA (0.50) GAASOS1KDM4EMAPTLMNA
SCHEMBL21028095 0.77 GAA (0.45) NOTUMGAACFTRKDM4EMAPT
SCHEMBL21028092 0.77 CFTR (0.63) GAACFTRKDM4EMAPTLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240254086-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT NIPPON SODA CO., LTD. (JP) 2024-08-01 US disclosed
EP-4339187-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT Nippon Soda Co., Ltd. (JP) 2024-03-20 EP disclosed
WO-2022239798-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-11-17 WO disclosed
WO-2022239798-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 2022-11-17 WO disclosed
WO-2021215393-A1 BENZAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 (JP) 2021-10-28 WO disclosed
WO-2021215393-A1 BENZAMIDE COMPOUND AND PEST CONTROL AGENT 日本曹達株式会社 (JP) 2021-10-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240254086-A1 (HETERO)ARYLAMIDE COMPOUND AND PEST CONTROL AGENT H1-2, CTRL, BOLA2; BOLA2B NOTUM 888/4885GAA 3136/4885SOS1 2012/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.