Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 7/20 | 0.48 |
| ▸ | CDK2 | P24941 | 7/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | CDK5 | Q00535 | 7/20 | 0.48 |
| ▸ | CDK5R1 | Q15078 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | CDK11A | Q9UQ88 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23930629 | 1.00 | MAPT (0.52) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL23930556 | 1.00 | MAPT (0.52) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL31633439 | 0.85 | MAPT (0.48) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL25199339 | 0.85 | MAPT (0.48) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL30210864 | 0.85 | MAPT (0.49) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL23930494 | 0.85 | MAPT (0.49) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL23930511 | 0.83 | CCNA2 (0.60) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL23930463 | 0.81 | MAPT (0.57) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL23930590 | 0.81 | MAPT (0.49) | MAPTMEN1KMT2APOLBTP53 | |
| SCHEMBL30210943 | 0.81 | MAPT (0.49) | MAPTMEN1KMT2APOLBTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139287-B1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AG (DE) | 2025-02-26 | — | — | EP | disclosed |
| EP-4139287-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | Bayer Aktiengesellschaft (DE) | 2023-03-01 | — | — | EP | disclosed |
| CN-115697979-A | Substituted aminothiazoles as DGKZETA inhibitors for immune activation | 拜耳公司 | 2023-02-03 | — | — | CN | disclosed |
| WO-2021214020-A1 | SUBSTITUTED AMINOTHIAZOLES AS DGKZETA INHIBITORS FOR IMMUNE ACTIVATION | BAYER AKTIENGESELLSCHAFT (DE) | 2021-10-28 | — | — | WO | disclosed |