Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Itraconazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 19/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | CYP51A1 | Q16850 | 3/20 | 1.00 |
| ▸ | FYN | P06241 | 2/20 | 1.00 |
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 2/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | MAPK1 | P28482 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 2/20 | 1.00 |
| ▸ | CYP8B1 | Q9UNU6 | 2/20 | 1.00 |
| ▸ | CXCR1 | P25024 | 1/20 | 1.00 |
| ▸ | TACR1 | P25103 | 1/20 | 1.00 |
| ▸ | AVPR2 | P30518 | 1/20 | 1.00 |
| ▸ | CCR4 | P51679 | 1/20 | 1.00 |
| ▸ | PDE4D | Q08499 | 1/20 | 1.00 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.75 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.75 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Itraconazole SCHEMBL14875797 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL16984893 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL14875705 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL18073409 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL15948108 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL18241650 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL20464865 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL14875903 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL64913 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN | |
| Itraconazole SCHEMBL13575828 | 1.00 | CYP3A4 (1.00) | CYP3A4ABCG2LMNACYP51A1FYN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 59410 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-122090921-A | Screening method and application of ATF3 and Importin alpha interaction inhibitor | — | 2026-05-26 | — | — | CN | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| WO-2026107113-A1 | MODIFIED CELLS FOR PROGRAMMING EXTRA ENVELOPED VIRUSES (EEVs) AND THEIR USE FOR PRODUCING THE EEVs, THE PROGRAMMED EEVs AND USES THEREOF | CALIDI BIOTHERAPEUTICS (NEVADA), INC. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4149415-B1 | SHAMPOO COMPOSITION COMPRISING ALKYL GLUCOSIDE | PROCTER & GAMBLE (US) | 2026-05-20 | — | — | EP | claimed |
| EP-4744729-A2 | METHODS OF TREATING GASTROINTESTINAL STROMAL TUMORS | Deciphera Pharmaceuticals, LLC (US) | 2026-05-20 | — | — | EP | claimed |
| US-12629363-B2 | Prophylaxis and treatment of angioedema | PHARVARIS GMBH (CH) | 2026-05-19 | — | — | US | claimed |
| WO-2026102345-A1 | METHODS OF ADMINISTERING THE VOLTAGE-GATED POTASSIUM CHANNEL OPENER AZETUKALNER | XENON PHARMACEUTICALS INC. (CA) | 2026-05-15 | — | — | WO | claimed |
| US-20260124224-A1 | USE OF COMBINED COMPOSITION IN PREPARING DRUG FOR RESISTING FUNGAL AND BACTERIAL INFECTIONS | NATIONAL CENTER FOR NANOSCIENCE AND TECHNOLOGY (CN) | 2026-05-07 | — | — | US | claimed |
| EP-4735045-A2 | OXAZAPHOSPHORINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE | La Life Products, LLC (US) | 2026-05-06 | — | — | EP | claimed |
| EP-4255391-B1 | LUMINOL FOR USE IN THE TREATMENT OF SEQUELAE OF A SARS-COV-2 INFECTION | METRIOPHARM AG (CH) | 2026-05-06 | — | — | EP | claimed |
| US-4861580-A | Composition using salt form of organic acid derivative of alpha-tocopheral | THE LIPOSOME COMPANY, INC. (US) | 1989-08-29 | — | — | US | claimed |
| EP-0310122-A1 | Antifungal composition | KAKEN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | claimed |
| EP-0243446-A4 | ALPHA TOCOPHEROL-BASED VESICLES. | LIPOSOME CO INC (US) | 1988-06-23 | — | — | EP | claimed |
| EP-0222771-A4 | STEROIDAL LIPOSOMES. | LIPOSOME CORP (US) | 1988-06-08 | — | — | EP | claimed |
| EP-0243446-A1 | ALPHA TOCOPHEROL-BASED VESICLES. | LIPOSOME CO INC (US) | 1987-11-04 | — | — | EP | claimed |
| EP-0222771-A1 | STEROIDAL LIPOSOMES | THE LIPOSOME COMPANY, INC. (US) | 1987-05-27 | — | — | EP | claimed |
| WO-1987002219-A1 | ALPHA TOCOPHEROL-BASED VESICLES | THE LIPOSOME COMPANY, INC. (US) | 1987-04-23 | — | — | WO | claimed |
| WO-1986005977-A1 | STEROIDAL LIPOSOMES | THE LIPOSOME COMPANY, INC. (US) | 1986-10-23 | — | — | WO | claimed |
| EP-0197571-A2 | Novel derivatives of gamma-cyclodextrin | JANSSEN PHARMACEUTICA N.V. (BE) | 1986-10-15 | — | — | EP | claimed |
| WO-1985002767-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING DRUGS WHICH ARE INSTABLE OR SPARINGLY SOLUBLE IN WATER AND METHODS FOR THEIR PREPARATION | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-07-04 | — | — | WO | claimed |