Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 15/20 | 0.41 |
| ▸ | JAK2 | O60674 | 9/20 | 0.41 |
| ▸ | JAK3 | P52333 | 6/20 | 0.38 |
| ▸ | TYK2 | P29597 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935138 | 0.80 | JAK1 (0.41) | JAK1JAK2JAK3TYK2ATM | |
| SCHEMBL23935168 | 0.80 | JAK1 (0.42) | JAK1JAK2JAK3TYK2LRRK2 | |
| SCHEMBL23935061 | 0.78 | JAK1 (0.41) | JAK1JAK2JAK3TYK2LRRK2 | |
| SCHEMBL23935057 | 0.77 | JAK1 (0.40) | JAK1JAK2JAK3TYK2LRRK2 | |
| SCHEMBL23934969 | 0.76 | JAK1 (0.41) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL18658798 | 0.75 | JAK1 (0.40) | JAK1JAK2JAK3TYK2LRRK2 | |
| SCHEMBL18658951 | 0.75 | JAK1 (0.40) | JAK1JAK2JAK3TYK2LRRK2 | |
| SCHEMBL18606613 | 0.75 | LRRK2 (0.43) | JAK1JAK2JAK3LRRK2 | |
| SCHEMBL23935181 | 0.74 | JAK1 (0.38) | JAK1JAK2JAK3TYK2LRRK2 | |
| SCHEMBL18606385 | 0.74 | LRRK2 (0.59) | JAK1JAK2JAK3LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |