Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.48 |
| ▸ | AKT1 | P31749 | 2/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23935016 | 0.83 | LRRK2 (0.49) | LRRK2PDPK1AKT1PIK3CDPIK3CA | |
| SCHEMBL23935191 | 0.83 | LRRK2 (0.54) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL23934965 | 0.82 | LRRK2 (0.49) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL23935165 | 0.82 | LRRK2 (0.51) | LRRK2PDPK1AKT1PIK3CDPIK3CA | |
| SCHEMBL25022746 | 0.81 | LRRK2 (0.63) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL23935094 | 0.81 | LRRK2 (0.50) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL23935040 | 0.81 | LRRK2 (0.67) | LRRK2 | |
| SCHEMBL23935032 | 0.81 | LRRK2 (0.56) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL23935127 | 0.80 | LRRK2 (0.43) | LRRK2PIK3CDPIK3CA | |
| SCHEMBL23935012 | 0.80 | LRRK2 (0.43) | LRRK2PIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350178-B1 | NOVEL IMIDAZO [4,5-C]QUINOLINE AND IMIDAZO [4,5-C][1,5]NAPHTHYRIDINE DERIVATIVES AS LRRK2 INHIBITORS | PFIZER (US) | 2021-10-20 | — | — | EP | disclosed |