Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | PRKCI | P41743 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.30 |
| ▸ | CFB | P00751 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2628879 | 0.80 | PRKCI (0.47) | PIK3C3AXLPRKCIKDM4EALDH1A1 | |
| SCHEMBL13674925 | 0.80 | KDM4E (0.33) | AXLPRKCIKDM4EALDH1A1LMNA | |
| SCHEMBL2674588 | 0.77 | PIK3C3 (0.41) | PIK3C3AXLPRKCIPARP1CFB | |
| SCHEMBL2633340 | 0.77 | PIK3C3 (0.41) | PIK3C3AXLPRKCIRPS6KA3NUDT1 | |
| SCHEMBL24809823 | 0.77 | PIK3C3 (0.41) | PIK3C3AXLPRKCI | |
| SCHEMBL2628875 | 0.77 | PIK3C3 (0.41) | PIK3C3AXLPRKCIPARP1 | |
| SCHEMBL8737717 | 0.76 | PIK3C3 (0.40) | PIK3C3AXLPRKCI | |
| SCHEMBL10292445 | 0.74 | PIK3C3 (0.39) | PIK3C3AXLPRKCIBRD4CFB | |
| SCHEMBL8737415 | 0.72 | AXL (0.47) | PIK3C3AXLPRKCIRPS6KA3GRM5 | |
| SCHEMBL20674133 | 0.71 | HTT (0.35) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |