Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.35 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.35 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.35 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20674637 | 0.83 | BAZ2B (0.37) | PTPN1PTPN2KMT2ABRD9BAZ2B | |
| SCHEMBL8234959 | 0.71 | PTPN1 (0.60) | PTPN1PTPN2KMT2AMAPK1SSTR4 | |
| SCHEMBL20674162 | 0.70 | BAZ2B (0.37) | PTPN1PTPN2KMT2ABRD9BAZ2B | |
| SCHEMBL20674631 | 0.69 | BAZ2B (0.41) | PTPN1PTPN2KMT2ABRD9BAZ2B | |
| SCHEMBL20674504 | 0.68 | PTPN1 (0.56) | PTPN1PTPN2KMT2AMAPK1SSTR4 | |
| SCHEMBL31452714 | 0.68 | PTPN1 (0.56) | PTPN1PTPN2KMT2ASSTR4PDE10A | |
| SCHEMBL19100165 | 0.68 | PTPN1 (0.56) | PTPN1PTPN2KMT2AMAPK1SSTR4 | |
| SCHEMBL29805590 | 0.68 | PTPN1 (0.51) | PTPN1PTPN2KMT2AMAPK1SSTR4 | |
| SCHEMBL13325875 | 0.67 | PTPN1 (0.55) | PTPN1PTPN2KMT2AMAPK1PDE10A | |
| SCHEMBL24656575 | 0.67 | PTPN1 (0.50) | PTPN1PTPN2KMT2ASSTR4PDE10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |