Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 3/20 | 0.51 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.51 |
| ▸ | SSTR4 | P31391 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20805122 | 0.84 | PTPN1 (0.58) | PTPN1PTPN2SSTR4HSD17B10LMNA | |
| SCHEMBL16256059 | 0.81 | PTPN1 (0.50) | PTPN1PTPN2SSTR4HSD17B10LMNA | |
| SCHEMBL25527271 | 0.79 | SSTR4 (0.46) | PTPN1PTPN2SSTR4HSD17B10MAPK1 | |
| SCHEMBL8234959 | 0.79 | PTPN1 (0.60) | PTPN1PTPN2SSTR4HSD17B10MAPK1 | |
| SCHEMBL20674538 | 0.79 | HSD17B10 (0.39) | SSTR4HSD17B10MAPK1LMNATSHR | |
| SCHEMBL23587117 | 0.76 | CYP1A2 (0.42) | SSTR4HSD17B10MAPK1KDM4EALDH1A1 | |
| SCHEMBL937960 | 0.75 | SSTR4 (0.48) | SSTR4HSD17B10MAPK1LMNATSHR | |
| SCHEMBL7499354 | 0.73 | PTGS1 (0.45) | SSTR4HSD17B10MAPK1HPGD | |
| SCHEMBL7373417 | 0.73 | CYP1A2 (0.40) | SSTR4LMNAKDM4EALDH1A1KMT2A | |
| SCHEMBL20654279 | 0.72 | SSTR4 (0.37) | SSTR4HSD17B10MAPK1LMNATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |