Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.30 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24092401 | 0.86 | HCAR2 (0.32) | HCAR2KMT2ATSHR | |
| SCHEMBL17232788 | 0.76 | HCAR2 (0.34) | HCAR2HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL31586479 | 0.76 | HCAR2 (0.34) | HCAR2HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL2849885 | 0.74 | HCAR2 (0.72) | HCAR2KMT2ATSHR | |
| SCHEMBL17229743 | 0.73 | HCAR2 (0.33) | HCAR2 | |
| SCHEMBL30226021 | 0.73 | HCAR2 (0.51) | HCAR2KMT2ATSHR | |
| SCHEMBL15330214 | 0.72 | HCAR2 (0.35) | HCAR2 | |
| SCHEMBL1423633 | 0.72 | HDAC1 (0.37) | HCAR2HDAC1HDAC8HDAC6HDAC5 | |
| SCHEMBL17234794 | 0.72 | HSD17B10 (0.35) | HCAR2TSHRHDAC1HDAC8HDAC6 | |
| SCHEMBL15996017 | 0.70 | HCAR2 (0.53) | HCAR2KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |