Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21958679 | 0.78 | — | — | |
| SCHEMBL14752475 | 0.76 | PARP1 (0.43) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL14752431 | 0.74 | PARP1 (0.42) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL14738222 | 0.74 | POLB (0.38) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL17045335 | 0.74 | POLB (0.38) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL17621554 | 0.74 | POLB (0.38) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL21196044 | 0.74 | CYP2C19 (0.34) | MAPTGAAMEN1KMT2ALMNA | |
| SCHEMBL3797366 | 0.74 | BRD4 (0.46) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL20430541 | 0.72 | POLB (0.37) | BRD4POLBMAPTTDP1L3MBTL1 | |
| SCHEMBL14737125 | 0.72 | POLB (0.37) | BRD4POLBMAPTTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3399968-B1 | SELECTIVE INHIBITORS OF CLINICALLY IMPORTANT MUTANTS OF THE EGFR TYROSINE KINASE | CS PHARMATECH LTD (KY) | 2021-10-20 | — | — | EP | disclosed |