Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.41 |
| ▸ | MAPK13 | O15264 | 12/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396409 | 0.94 | MAPK14 (0.40) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL1725624 | 0.82 | MAPK13 (0.40) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL2394531 | 0.81 | MAPK14 (0.48) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL1724433 | 0.79 | KDM4E (0.34) | — | |
| SCHEMBL2396466 | 0.78 | MAPK14 (0.47) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL1722984 | 0.77 | MAPK14 (0.42) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL1725218 | 0.77 | MAPK14 (0.47) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL2394931 | 0.76 | MAPK14 (0.47) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL1724948 | 0.76 | MAPK14 (0.39) | MAPK14MAPK13CYP2C9 | |
| SCHEMBL2398373 | 0.76 | MAPK14 (0.41) | MAPK14MAPK13CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012980-B2 | Isoquinolinone derivatives | ASTRAZENECA AB (SE) | 2011-09-06 | — | — | US | disclosed |