Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.50 |
| ▸ | CCR2 | P41597 | 3/20 | 0.50 |
| ▸ | TACR1 | P25103 | 15/20 | 0.43 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24433932 | 0.85 | KCNH2 (0.48) | KCNH2CCR2TACR1ADAMTS5DPP4 | |
| SCHEMBL21900723 | 0.85 | KCNH2 (0.48) | KCNH2CCR2TACR1ADAMTS5DPP4 | |
| SCHEMBL18252874 | 0.84 | KCNH2 (0.48) | KCNH2CCR2TACR1ADAMTS5DPP4 | |
| SCHEMBL18244998 | 0.82 | TACR1 (0.46) | KCNH2CCR2TACR1ADAMTS5DPP4 | |
| SCHEMBL18252890 | 0.79 | KCNH2 (0.46) | KCNH2CCR2TACR1 | |
| SCHEMBL24433859 | 0.79 | TACR1 (0.43) | KCNH2CCR2TACR1 | |
| SCHEMBL21900422 | 0.79 | TACR1 (0.43) | KCNH2CCR2TACR1 | |
| SCHEMBL19443100 | 0.79 | TACR1 (0.43) | KCNH2CCR2TACR1 | |
| SCHEMBL3863239 | 0.78 | KCNH2 (0.63) | KCNH2CCR2TACR1 | |
| SCHEMBL13645885 | 0.78 | KCNH2 (0.63) | KCNH2CCR2TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3297438-B1 | CCR2 MODULATORS | CHEMOCENTRYX INC (US) | 2021-10-20 | — | — | EP | disclosed |