Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 7/20 | 0.41 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 11/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP11A1 | P05108 | 1/20 | 0.36 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.36 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4637001 | 0.75 | — | — | |
| SCHEMBL21591965 | 0.73 | CRBN (0.42) | CRBNDDB1CYP19A1CYP3A4TBXAS1 | |
| SCHEMBL21848668 | 0.71 | CRBN (0.41) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| SCHEMBL632775 | 0.71 | CRBN (0.41) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| SCHEMBL23386181 | 0.71 | CRBN (0.41) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| SCHEMBL8259939 | 0.71 | CRBN (0.41) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| Bromide SCHEMBL283607 | 0.70 | CRBN (0.40) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| Bromide SCHEMBL283263 | 0.70 | CRBN (0.40) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| Hydrochloric Acid SCHEMBL18449191 | 0.70 | CRBN (0.40) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 | |
| Bromide SCHEMBL283262 | 0.70 | CRBN (0.40) | CRBNCYP19A1CYP3A4TBXAS1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-10-20 | — | — | EP | disclosed |