Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | LTA4H | P09960 | 2/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | GBA1 | P04062 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20314846 | 0.85 | KDM4E (0.51) | KDM4EALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL20334629 | 0.83 | KDM4E (0.49) | KDM4EALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL9945956 | 0.82 | CARM1 (0.42) | KDM4EMAPTLTA4H | |
| SCHEMBL30174322 | 0.82 | MAPT (0.55) | KDM4EALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL22831332 | 0.82 | MAPT (0.55) | KDM4EALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL24107339 | 0.81 | CARM1 (0.41) | KDM4ETDP1 | |
| SCHEMBL18488070 | 0.81 | FFAR1 (0.44) | KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL23278125 | 0.80 | KDM4E (0.53) | KDM4EALDH1A1MAPTCHRNB2CHRNA4 | |
| SCHEMBL17658890 | 0.80 | NQO1 (0.48) | ALDH1A1MAPTTDP1SMN1; SMN2 | |
| SCHEMBL18488073 | 0.79 | CARM1 (0.43) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3643709-B1 | ISOINDOLINE DERIVATIVE, INTERMEDIATE, PREPARATION METHOD, PHARMACEUTICAL COMPOSITION AND USE THEREOF | KANGPU BIOPHARMACEUTICALS LTD (CN) | 2021-10-20 | — | — | EP | disclosed |