Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK2 | P49760 | 2/20 | 0.42 |
| ▸ | CLK3 | P49761 | 2/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.42 |
| ▸ | CDK7 | P50613 | 2/20 | 0.41 |
| ▸ | MTOR | P42345 | 8/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 3/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.37 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | CDC7 | O00311 | 2/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558782 | 0.91 | MTOR (0.42) | DYRK1ACDK7MTORPIK3CAPIK3CD | |
| SCHEMBL1558598 | 0.90 | PDPK1 (0.44) | CDK7MTORPIK3CAPIK3CDLRRK2 | |
| SCHEMBL12266421 | 0.88 | MTOR (0.42) | CDK7MTORCYP11B1CYP11B2PRMT5 | |
| SCHEMBL2396054 | 0.87 | MAP4K4 (0.46) | CDK7MTORCYP11B1CYP11B2PRMT5 | |
| SCHEMBL1559244 | 0.87 | CLK2 (0.43) | CLK2CLK3DYRK1ACDK7MTOR | |
| SCHEMBL1558604 | 0.86 | PDPK1 (0.41) | CLK2CLK3DYRK1ACDK7MTOR | |
| SCHEMBL2396765 | 0.86 | MTOR (0.41) | DYRK1ACDK7MTORPIK3CAPIK3CD | |
| SCHEMBL1558156 | 0.85 | MTOR (0.55) | CDK7MTORPIK3CAPIK3CDLRRK2 | |
| SCHEMBL1557499 | 0.84 | MKNK1 (0.44) | CLK2CLK3DYRK1ACDK7MTOR | |
| SCHEMBL2400097 | 0.84 | FGFR2 (0.46) | CDK7MTORPIK3CAPIK3CDLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | CLK2 408/4885CLK3 506/4885DYRK1A 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.