Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 8/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 16/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21561485 | 0.88 | ERBB2 (0.53) | EGFRERBB2AAK1 | |
| SCHEMBL21561475 | 0.87 | EGFR (0.54) | EGFRERBB2AAK1 | |
| SCHEMBL21561483 | 0.85 | ERBB2 (0.58) | EGFRERBB2AAK1 | |
| SCHEMBL21561482 | 0.79 | ERBB2 (0.52) | EGFRERBB2AAK1 | |
| SCHEMBL21561498 | 0.79 | ERBB2 (0.51) | EGFRERBB2 | |
| SCHEMBL21561466 | 0.78 | ERBB2 (0.56) | EGFRERBB2AAK1 | |
| SCHEMBL21561484 | 0.78 | EGFR (0.67) | EGFRERBB2AAK1 | |
| SCHEMBL21561474 | 0.77 | ERBB2 (0.52) | EGFRERBB2 | |
| SCHEMBL21561481 | 0.77 | TTBK1 (0.58) | EGFRERBB2 | |
| SCHEMBL21561471 | 0.76 | ERBB2 (0.51) | EGFRERBB2AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | MEDSHINE DISCOVERY INC. (CN) | 2024-07-09 | — | — | US | disclosed |
| US-20210323979-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12030897-B2 | Pyrrolo[2,1-f][1,2,4]triazine derivatives serving as selective HER2 inhibitors and application thereof | ERBB2, EGFR, ERBB3 | EGFR 2/4885ERBB2 1/4885AAK1 458/4885 |
| US-20210323979-A1 | PYRROLO[2,1-F][1,2,4]TRIAZINE DERIVATIVES SERVING AS SELECTIVE HER2 INHIBITORS AND APPLICATION THEREOF | ERBB2, EGFR, ERBB3 | EGFR 2/4885ERBB2 1/4885AAK1 458/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.