Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.64 |
| ▸ | IGF1R | P08069 | 7/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.40 |
| ▸ | INSR | P06213 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18239603 | 0.90 | EGFR (0.74) | EGFRIGF1RKCNH2INSR | |
| SCHEMBL18239605 | 0.87 | EGFR (0.59) | EGFRIGF1RKCNH2INSR | |
| SCHEMBL18202149 | 0.82 | EGFR (0.64) | EGFRIGF1RKCNH2 | |
| SCHEMBL18239598 | 0.81 | EGFR (0.76) | EGFRIGF1RKCNH2INSR | |
| SCHEMBL18239606 | 0.81 | EGFR (0.62) | EGFRIGF1RKCNH2 | |
| SCHEMBL18202145 | 0.81 | EGFR (0.51) | EGFRIGF1RKCNH2 | |
| SCHEMBL18202150 | 0.80 | EGFR (0.56) | EGFRIGF1RKCNH2 | |
| SCHEMBL22510208 | 0.79 | EGFR (0.60) | EGFRIGF1RKCNH2 | |
| SCHEMBL18202334 | 0.78 | EGFR (0.73) | EGFRKCNH2INSR | |
| SCHEMBL18229913 | 0.78 | EGFR (1.00) | EGFRIGF1RKCNH2INSR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210323976-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ARIAD PHARMACEUTICALS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323976-A1 | HETEROARYL COMPOUNDS FOR KINASE INHIBITION | ERBB2, EGFR, ERBB3 | EGFR 2/4885IGF1R 384/4885KCNH2 4480/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.