Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.31 |
| ▸ | DRD2 | P14416 | 3/20 | 0.30 |
| ▸ | DRD4 | P21917 | 3/20 | 0.30 |
| ▸ | DRD3 | P35462 | 3/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23560035 | 0.87 | HRH3 (0.49) | HRH3PIK3CDNAMPTCYP2D6MEN1 | |
| SCHEMBL21107505 | 0.83 | HRH3 (0.40) | HRH3PIK3CDCYP2D6MEN1KMT2A | |
| SCHEMBL24608232 | 0.82 | HRH3 (0.45) | HRH3PIK3CDNAMPTCYP2D6MEN1 | |
| SCHEMBL23518741 | 0.81 | PIK3CD (0.38) | HRH3PIK3CDCYP2D6KDM4EALDH1A1 | |
| SCHEMBL22794102 | 0.80 | HRH3 (0.44) | HRH3PIK3CDNAMPTCYP2D6MEN1 | |
| SCHEMBL23560049 | 0.80 | HRH3 (0.44) | HRH3PIK3CDNAMPTCYP2D6MEN1 | |
| SCHEMBL23134534 | 0.80 | HRH3 (0.48) | HRH3PIK3CDNAMPTCYP2D6MEN1 | |
| SCHEMBL23568927 | 0.79 | HRH3 (0.43) | HRH3PIK3CDNAMPTCYP2D6MEN1 | |
| SCHEMBL22794841 | 0.79 | HRH3 (0.43) | HRH3PIK3CD | |
| SCHEMBL23695845 | 0.77 | HRH3 (0.42) | HRH3PIK3CDDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | HRH3 3631/4885PIK3CD 321/4885NAMPT 1694/4885 |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | HRH3 3631/4885PIK3CD 321/4885NAMPT 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.