Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23945684 | 0.95 | MEN1 (0.49) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL25654222 | 0.94 | MEN1 (0.41) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL24764547 | 0.82 | KDM4E (0.35) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL22837626 | 0.82 | MEN1 (0.49) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL25654205 | 0.81 | KDM4E (0.34) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL21106810 | 0.81 | KMT2A (0.56) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL26406203 | 0.81 | MEN1 (0.47) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL25921828 | 0.79 | MEN1 (0.44) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL23696307 | 0.79 | KDM4E (0.38) | MEN1KMT2AKDM4ECYP1A2CYP2D6 | |
| SCHEMBL21106975 | 0.79 | KDM4E (0.38) | MEN1KMT2AKDM4ECYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2022-06-07 | — | — | US | disclosed |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11352350-B2 | IRAK degraders and uses thereof | IRAK2, IRAK3, IRAK1 | MEN1 4055/4885KMT2A 445/4885KDM4E 190/4885 |
| US-20210323952-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | MEN1 4055/4885KMT2A 445/4885KDM4E 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.