Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888443 | 0.86 | NPC1 (0.48) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2400510 | 0.81 | MEN1 (0.41) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2396335 | 0.81 | PIK3CD (0.57) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2395755 | 0.81 | MEN1 (0.60) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2395910 | 0.80 | MEN1 (0.60) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2398099 | 0.79 | MEN1 (0.45) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL1891863 | 0.77 | KDR (0.41) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2395328 | 0.76 | KDR (0.49) | KMT2AMEN1ALDH1A1NPC1RAB9A | |
| SCHEMBL2395311 | 0.75 | PIK3C2G (0.42) | KMT2AMEN1ALDH1A1PIK3CAPIK3CG | |
| SCHEMBL2398117 | 0.73 | PIK3CD (0.50) | KMT2AMEN1PIK3CAPIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |