Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.45 |
| ▸ | HTR1D | P28221 | 8/20 | 0.43 |
| ▸ | HTR1B | P28222 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 1/20 | 0.43 |
| ▸ | HTR1F | P30939 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | BCR | P11274 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22885957 | 0.93 | PTPN22 (1.00) | PTPN22KDM4EABL1BCR | |
| SCHEMBL23923885 | 0.93 | PTPN22 (1.00) | PTPN22KDM4EABL1BCR | |
| SCHEMBL23947391 | 0.93 | PTPN22 (1.00) | PTPN22KDM4EABL1BCR | |
| SCHEMBL23947528 | 0.92 | PTPN22 (0.85) | PTPN22KDM4EHPGDHSD17B10ABL1 | |
| SCHEMBL23948028 | 0.92 | PTPN22 (0.88) | PTPN22KDM4EHPGDHSD17B10ABL1 | |
| SCHEMBL23947561 | 0.91 | PTPN22 (0.86) | PTPN22KDM4EABL1BCRKMT2A | |
| SCHEMBL23947360 | 0.89 | PTPN22 (0.83) | PTPN22KDM4EHPGDHSD17B10ABL1 | |
| SCHEMBL23947590 | 0.89 | PTPN22 (0.83) | PTPN22POLBMAPT | |
| SCHEMBL23947589 | 0.86 | PTPN22 (0.88) | PTPN22KDM4EABL1BCRKMT2A | |
| SCHEMBL23947530 | 0.85 | PTPN22 (0.79) | PTPN22KDM4EABL1BCRKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021211191-A1 | NOVEL LYMPHOID-SPECIFIC TYROSINE PHOSPHATASE (LYP) INHIBITORS | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | WO | disclosed |
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PURDUE RESEARCH FOUNDATION (US) | 2021-10-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210323926-A1 | Novel Lymphoid-Specific Tyrosine Phosphatase (LYP) Inhibitors | PTPN22, PTPN1, PTPRCAP | PTPN22 1/4885KDM4E 533/4885HPGD 4158/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.