Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 18/20 | 0.70 |
| ▸ | CHRM2 | P08172 | 11/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | KMO | O15229 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23932171 | 1.00 | CHRM4 (0.70) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932166 | 1.00 | CHRM4 (0.70) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932169 | 1.00 | CHRM4 (0.70) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932218 | 0.85 | CHRM4 (0.62) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932216 | 0.85 | CHRM4 (0.62) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932221 | 0.85 | CHRM4 (0.62) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932246 | 0.84 | CHRM4 (0.75) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932245 | 0.84 | CHRM4 (0.75) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23932244 | 0.84 | CHRM4 (0.75) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 | |
| SCHEMBL23523105 | 0.82 | CHRM4 (1.00) | CHRM4CHRM2CYP1A2CYP3A4CYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212819-A1 | INDAZOLE DERIVATIVES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022140499-A1 | ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2022-06-30 | — | — | WO | disclosed |
| WO-2021216949-A1 | CONDENSED SUBSTITUTED HYDROPYRROLES AS ANTAGONISTS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY (US) | 2021-10-28 | — | — | WO | disclosed |