Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITK | Q08881 | 13/20 | 0.45 |
| ▸ | LCK | P06239 | 13/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 12/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | INSR | P06213 | 1/20 | 0.41 |
| ▸ | TEC | P42680 | 1/20 | 0.41 |
| ▸ | TXK | P42681 | 1/20 | 0.41 |
| ▸ | BMX | P51813 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395694 | 1.00 | ITK (0.45) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2396118 | 0.93 | ITK (0.44) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2396127 | 0.93 | ITK (0.44) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2371013 | 0.88 | ITK (0.47) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2371003 | 0.88 | ITK (0.47) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2370066 | 0.83 | ITK (0.40) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2370069 | 0.83 | ITK (0.40) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2397085 | 0.82 | ITK (0.47) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2397090 | 0.82 | ITK (0.47) | ITKLCKAURKBSRCEGFR | |
| SCHEMBL2399126 | 0.81 | ITK (0.49) | ITKLCKAURKBSRCEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011110575-A1 | DERIVATIVES OF 2-[2-(BENZO- OR PYRIDO-) THIAZOLYLAMINO]-6-AMINOPYRIDINE, USEFUL IN THE TREATMENT OF RESPIRATORIC, ALLERGIC OR INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2011-09-15 | — | — | WO | disclosed |