Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 6/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 6/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 6/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 6/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 6/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | PPOX | P50336 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ACACB | O00763 | 1/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23957151 | 0.88 | HDAC3 (0.55) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL31020827 | 0.87 | HDAC3 (0.54) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL23928850 | 0.87 | HDAC3 (0.54) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL11107269 | 0.83 | KDM4E (0.56) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL617446 | 0.83 | KDM4E (0.52) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL23957089 | 0.82 | HDAC3 (0.46) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL21617952 | 0.81 | HDAC3 (0.45) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL30016232 | 0.81 | HDAC3 (0.48) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL23957134 | 0.79 | HDAC3 (0.44) | HDAC8HDAC6HDAC3HDAC4HDAC1 | |
| SCHEMBL23957116 | 0.78 | ATM (0.55) | HDAC8HDAC6HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | RICHTER GEDEON NYRT. (HU) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210330650-A1 | SPIROCHROMANE DERIVATIVES | CHRNA7, CHRM3, ADRB3 | HDAC8 222/4885HDAC6 537/4885HDAC3 120/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.