Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | WNT3A | P56704 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CCNK | O75909 | 1/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21275921 | 0.90 | HDAC3 (0.62) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20181660 | 0.89 | KCNH2 (0.58) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20181718 | 0.88 | HDAC3 (0.57) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL23960936 | 0.88 | MEN1 (0.54) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20163065 | 0.87 | HDAC2 (0.54) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20163064 | 0.87 | MEN1 (0.51) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20181517 | 0.85 | HDAC2 (0.55) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20163050 | 0.85 | HDAC3 (0.60) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL20163093 | 0.85 | HDAC3 (0.60) | SMN1; SMN2MEN1MAPTTSHRKMT2A | |
| SCHEMBL23961031 | 0.84 | HDAC3 (0.62) | HDAC3KCNH2CYP1A2CYP2C18CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210332036-A1 | PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS LLC (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332036-A1 | PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | SMN1; SMN2 1802/4885MEN1 4613/4885MAPT 1952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.