Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 13/20 | 0.85 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 11/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C18 | P33260 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20181491 | 0.92 | HDAC3 (1.00) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL20181654 | 0.87 | HDAC3 (0.81) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL23961031 | 0.85 | HDAC3 (0.62) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL23960885 | 0.81 | HDAC3 (0.81) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL20181734 | 0.81 | HDAC3 (1.00) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL13738638 | 0.81 | HDAC1 (1.00) | HDAC3HDAC2HDAC1 | |
| SCHEMBL1067590 | 0.78 | HDAC3 (0.76) | HDAC3HDAC2HDAC1KCNH2 | |
| SCHEMBL20181636 | 0.78 | HDAC2 (1.00) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL21275921 | 0.78 | HDAC3 (0.62) | HDAC3HDAC2HDAC1KCNH2CYP1A2 | |
| SCHEMBL25161044 | 0.78 | HDAC3 (0.69) | HDAC3HDAC2HDAC1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210332036-A1 | PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS | REGENACY PHARMACEUTICALS LLC (US) | 2021-10-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210332036-A1 | PYRIMIDINE AND PYRAZINE HDAC1,2 INHIBITORS | HDAC1, HDAC2, HDAC11 | HDAC3 7/4885HDAC2 2/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.