Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 10/20 | 0.73 |
| ▸ | KDR | P35968 | 12/20 | 0.62 |
| ▸ | RET | P07949 | 11/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.58 |
| ▸ | PIK3CG | P48736 | 8/20 | 0.58 |
| ▸ | ABL1 | P00519 | 6/20 | 0.58 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | HCK | P08631 | 6/20 | 0.58 |
| ▸ | SRC | P12931 | 6/20 | 0.58 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.58 |
| ▸ | MTOR | P42345 | 6/20 | 0.58 |
| ▸ | EPHB4 | P54760 | 6/20 | 0.58 |
| ▸ | PRKDC | P78527 | 6/20 | 0.58 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.58 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.58 |
| ▸ | CASK | O14936 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396283 | 1.00 | PIK3CD (0.73) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12422337 | 0.91 | PIK3CD (0.84) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12422304 | 0.91 | PIK3CD (0.84) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12422336 | 0.90 | PIK3CD (0.82) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12265338 | 0.89 | KDR (0.60) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12022201 | 0.89 | PIK3CD (0.87) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12313616 | 0.87 | KDR (0.60) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12422285 | 0.85 | PIK3CD (0.81) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL12422364 | 0.84 | PIK3CD (1.00) | PIK3CDKDRRETPIK3CAPIK3CG | |
| SCHEMBL18922370 | 0.84 | PIK3CD (0.80) | PIK3CDKDRRETPIK3CAPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102625708-A | Pi3 kinase inhibitors and uses thereof | AVILA THERAPEUTICS INC | 2012-08-01 | — | — | CN | disclosed |
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | PIK3CA, PIK3CB, PIK3C2B | PIK3CD 5/4885KDR 912/4885RET 642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.