Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | RORC | P51449 | 1/20 | 0.39 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.37 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16080210 | 0.89 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL30456121 | 0.87 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL21603201 | 0.86 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL25617959 | 0.86 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL12683334 | 0.86 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL16472381 | 0.86 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL13177350 | 0.85 | NR1H2 (0.59) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL29128147 | 0.85 | NR1H2 (0.59) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL14800658 | 0.85 | NR1H2 (0.59) | NR1H2USP2SMN1; SMN2USP30NAMPT | |
| SCHEMBL14800656 | 0.85 | NR1H2 (0.59) | NR1H2USP2SMN1; SMN2USP30NAMPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021215545-A1 | ANTICANCER COMBINATION THERAPY WITH N-(1-ACRYLOYL-AZETIDIN-3-YL)-2-((1H-INDAZOL-3-YL)AMINO)METHYL)-1H-IMIDAZOLE-5-CARBOXAMIDE INHIBITOR OF KRAS-G12C | TAIHO PHARMACEUTICAL CO., LTD. (JP) | 2021-10-28 | — | — | WO | disclosed |