Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.50 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | SLC22A16 | Q86VW1 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.31 |
| ▸ | CPT1A | P50416 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Isocitric Acid SCHEMBL7188284 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL19138174 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL2580919 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL6739636 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL1061380 | 0.95 | CA4 (0.54) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL2583035 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL11648770 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL2581302 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL6739630 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA | |
| Isocitric Acid SCHEMBL11483986 | 0.95 | CA4 (0.50) | CA4CTSLCA2SLC22A16LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8563538-B2 | Preventing and/or treating cardiovascular disease and/or associated heart failure | PHILERA NEW ZEALAND LIMITED (NZ) | 2013-10-22 | — | — | US | claimed |
| EP-1487431-B1 | PREVENTING AND/OR TREATING CARDIOVASCULAR DISEASE AND/OR ASSOCIATED HEART FAILURE | PHILERA NEW ZEALAND LTD (NZ) | 2012-05-02 | — | — | EP | claimed |
| US-8034799-B2 | Preventing and/or treating cardiovascular disease and/or associated heart failure | PHILERA NEW ZEALAND LIMITED (NZ) | 2011-10-11 | — | — | US | claimed |
| US-20110212188-A1 | PREVENTING AND/OR TREATING CARDIOVASCULAR DISEASE AND/OR ASSOCIATED HEART FAILURE | PHILERA NEW ZEALAND LIMITED (NZ) | 2011-09-01 | — | — | US | claimed |
| US-20060009534-A1 | Preventing and/or treating cardiovascular disease and/or associated heart failure | PHILERA NEW ZEALAND LIMITED (NZ) | 2006-01-12 | — | — | US | claimed |