Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 13/20 | 0.63 |
| ▸ | BRD4 | O60885 | 4/20 | 0.63 |
| ▸ | BRDT | Q58F21 | 4/20 | 0.63 |
| ▸ | MAPK7 | Q13164 | 2/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.54 |
| ▸ | TTK | P33981 | 1/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2396426 | 1.00 | PLK1 (0.63) | PLK1BRD4BRDTMAPK7RAD52 | |
| SCHEMBL2396194 | 0.90 | PLK1 (0.61) | PLK1BRD4BRDTMAPK7RAD52 | |
| SCHEMBL2397087 | 0.89 | PLK1 (0.62) | PLK1BRD4BRDTRAD52LRRK2 | |
| SCHEMBL2443742 | 0.89 | PLK1 (0.63) | PLK1BRD4BRDTMAPK7RAD52 | |
| SCHEMBL2394484 | 0.88 | PLK1 (0.61) | PLK1BRD4BRDTRAD52PTK2 | |
| SCHEMBL2394489 | 0.88 | PLK1 (0.61) | PLK1BRD4BRDTRAD52PTK2 | |
| SCHEMBL17506110 | 0.87 | PLK1 (0.66) | PLK1BRD4BRDTRAD52TTK | |
| SCHEMBL11890119 | 0.87 | PLK1 (0.66) | PLK1BRD4BRDTRAD52TTK | |
| SCHEMBL1202705 | 0.87 | PLK1 (0.68) | PLK1BRD4BRDTRAD52TTK | |
| SCHEMBL4297998 | 0.87 | PLK1 (0.65) | PLK1BRD4BRDTRAD52TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140038935-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-02-06 | — | — | US | disclosed |
| US-8394952-B2 | Dihydrodiazepines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-03-12 | — | — | US | disclosed |
| US-20120149898-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-06-14 | — | — | US | disclosed |
| US-8022202-B2 | Dihydrodiazepines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-09-20 | — | — | US | disclosed |
| EP-1983987-B1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMA (US) | 2010-09-01 | — | — | EP | disclosed |
| US-20100190765-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2010-07-29 | — | — | US | disclosed |
| US-7622463-B2 | Dihydrodiazepines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-11-24 | — | — | US | disclosed |
| US-20080167289-A1 | Dihydrodiazepines useful as inhibitors of protein kinases | VERTEX PHARMACEUTICALS INCORPORATED | 2008-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080167289-A1 | Dihydrodiazepines useful as inhibitors of protein kinases | MAP3K20, MAP3K5, MAP4K2 | PLK1 89/4885BRD4 536/4885BRDT 833/4885 |
| US-20140038935-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, MAP4K2 | PLK1 89/4885BRD4 536/4885BRDT 833/4885 |
| US-20120149898-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, MAP4K2 | PLK1 89/4885BRD4 536/4885BRDT 833/4885 |
| US-20100190765-A1 | DIHYDRODIAZEPINES USEFUL AS INHIBITORS OF PROTEIN KINASES | MAP3K20, MAP3K5, MAP4K2 | PLK1 89/4885BRD4 536/4885BRDT 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.