Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 12/20 | 0.62 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.40 |
| ▸ | HRH1 | P35367 | 3/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23914714 | 0.96 | S1PR2 (0.60) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23915479 | 0.89 | S1PR2 (0.67) | S1PR2ADRA1AHRH1ADRA1B | |
| SCHEMBL23914717 | 0.88 | S1PR2 (0.66) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23908762 | 0.87 | S1PR2 (0.66) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23914710 | 0.86 | S1PR2 (0.65) | S1PR2ADRA1AHRH1ADRA1BPARP1 | |
| SCHEMBL23915580 | 0.86 | S1PR2 (0.52) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23915339 | 0.85 | S1PR2 (0.68) | S1PR2LMNASMN1; SMN2TNKSPARP1 | |
| SCHEMBL23908864 | 0.85 | S1PR2 (0.65) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23908806 | 0.84 | S1PR2 (0.64) | S1PR2ADRA1AHRH1ADRA1BHRH3 | |
| SCHEMBL23913181 | 0.84 | S1PR2 (0.62) | S1PR2ADRA1AHRH1ADRA1BHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |