Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR2 | O95136 | 9/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23908890 | 0.94 | S1PR2 (0.66) | S1PR2KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL23908781 | 0.93 | S1PR2 (0.60) | S1PR2KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL23908871 | 0.93 | S1PR2 (0.60) | S1PR2KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL23908861 | 0.91 | S1PR2 (0.76) | S1PR2 | |
| SCHEMBL23914585 | 0.91 | S1PR2 (0.68) | S1PR2KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL23908790 | 0.90 | S1PR2 (0.61) | S1PR2KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL23908736 | 0.90 | S1PR2 (0.61) | S1PR2KDM4EHSD17B10MAPTSMN1; SMN2 | |
| SCHEMBL23909009 | 0.89 | S1PR2 (0.57) | S1PR2KDM4EHSD17B10POLBTP53 | |
| SCHEMBL23908910 | 0.89 | S1PR2 (0.61) | S1PR2KDM4EHSD17B10ALDH1A1MAPT | |
| SCHEMBL23908878 | 0.89 | S1PR2 (0.64) | S1PR2KDM4EHSD17B10MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |