Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23966683 | 0.79 | POLB (0.33) | POLB | |
| SCHEMBL25819150 | 0.76 | — | — | |
| SCHEMBL21719315 | 0.75 | ALOX5AP (0.31) | — | |
| SCHEMBL26021835 | 0.74 | POLB (0.38) | POLBNR3C1 | |
| SCHEMBL24033682 | 0.74 | ALOX5AP (0.30) | — | |
| SCHEMBL21101088 | 0.73 | POLB (0.34) | POLBPTGS1PTGS2 | |
| SCHEMBL12019751 | 0.72 | ALOX5AP (0.42) | — | |
| SCHEMBL25799816 | 0.71 | — | — | |
| SCHEMBL18068105 | 0.69 | POLB (0.37) | POLBPTGS1PTGS2 | |
| SCHEMBL19261370 | 0.68 | POLB (0.48) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161852-B1 | Inhibitors of NEK7 kinase | Halia Therapeutics, Inc. (US) | 2021-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11161852-B1 | Inhibitors of NEK7 kinase | NEK7, NEK1, NEK5 | POLB 3937/4885PTGS1 2809/4885PTGS2 3664/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.