Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 4/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23915640 | 0.84 | AKR1B1 (0.52) | AKR1B1S1PR2KDM4EHSD17B10GAA | |
| SCHEMBL23914637 | 0.83 | AKR1B1 (0.47) | AKR1B1S1PR2MAPTKDM4EGAA | |
| SCHEMBL23914932 | 0.83 | MAPT (0.58) | AKR1B1S1PR2MAPTGAAALOX15 | |
| SCHEMBL23909062 | 0.80 | AKR1B1 (0.52) | AKR1B1S1PR2KDM4EHSD17B10GAA | |
| SCHEMBL23908938 | 0.80 | S1PR2 (0.46) | AKR1B1S1PR2MAPTGAAPOLB | |
| SCHEMBL23909112 | 0.78 | S1PR2 (0.45) | AKR1B1S1PR2MAPTGAAALDH1A1 | |
| SCHEMBL23915403 | 0.76 | S1PR2 (0.48) | AKR1B1S1PR2KDM4EHSD17B10GAA | |
| SCHEMBL23914960 | 0.74 | S1PR2 (0.44) | AKR1B1S1PR2MAPTKDM4EHSD17B10 | |
| SCHEMBL23915510 | 0.73 | S1PR2 (0.58) | AKR1B1S1PR2MAPTKDM4EGAA | |
| SCHEMBL23966504 | 0.73 | NPC1 (0.47) | S1PR2MAPTKDM4EGAAALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3649119-B1 | NOVEL COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE TREATMENT OF FIBROSIS | GALAPAGOS NV (BE) | 2021-11-03 | — | — | EP | disclosed |