Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 10/20 | 0.40 |
| ▸ | CLK3 | P49761 | 10/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.40 |
| ▸ | WNT1 | P04628 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1558650 | 0.90 | MTOR (0.49) | MTORCLK2CLK3DYRK1AWNT1 | |
| SCHEMBL1557469 | 0.90 | CLK2 (0.51) | MTORCLK2CLK3DYRK1AWNT1 | |
| SCHEMBL2396806 | 0.87 | CLK2 (0.50) | MTORCLK2CLK3DYRK1AWNT1 | |
| Cyclopropane Carboxylic Acid SCHEMBL1557567 | 0.85 | CLK2 (0.48) | MTORCLK2CLK3DYRK1AWNT1 | |
| SCHEMBL2395780 | 0.85 | DYRK1A (0.48) | MAP4K4CLK2CLK3DYRK1AWNT1 | |
| SCHEMBL1557610 | 0.84 | PIK3CA (0.45) | MTORMAP4K4CLK2DYRK1A | |
| SCHEMBL1559115 | 0.83 | CLK2 (0.45) | MTORCLK2CLK3DYRK1AWNT1 | |
| SCHEMBL2396765 | 0.82 | MTOR (0.41) | MTORMAP4K4DYRK1AWNT1 | |
| SCHEMBL2395700 | 0.82 | CLK2 (0.40) | MTORCLK2CLK3DYRK1AWNT1 | |
| SCHEMBL1558762 | 0.82 | CDK7 (0.49) | MTORDYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | MTOR 26/4885MAP4K4 173/4885CLK2 408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.