Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 8/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 2/20 | 0.36 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2387443 | 0.86 | PDE10A (0.59) | PDE10ADHODHHSD17B10ALDH1A1KDM4E | |
| SCHEMBL1522076 | 0.86 | PDE10A (0.59) | PDE10AALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL14672689 | 0.79 | PDE10A (0.61) | PDE10AHSD17B10RAB9AMAPTTHRB | |
| SCHEMBL6891087 | 0.79 | PDE10A (0.57) | PDE10AALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL6892979 | 0.79 | PDE10A (0.57) | PDE10AALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL1457842 | 0.79 | PDE10A (0.53) | PDE10AHSD17B10ALDH1A1SMN1; SMN2KDM4E | |
| SCHEMBL1459314 | 0.79 | PDE10A (0.53) | PDE10A | |
| SCHEMBL6889352 | 0.79 | PDE10A (0.55) | PDE10AALDH1A1SMN1; SMN2KDM4EHPGD | |
| SCHEMBL6916987 | 0.78 | PDE10A (0.63) | PDE10AALDH1A1KDM4ERAB9AMAPT | |
| SCHEMBL1457763 | 0.78 | PDE10A (0.51) | PDE10AALDH1A1KDM4ETP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110237564-A1 | IMIDAZOPYRIMIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. | 2011-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110237564-A1 | IMIDAZOPYRIMIDINE DERIVATIVES | PDE5A, PDE3B, PDE3A | PDE10A 10/4885DHODH 224/4885HSD17B10 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.