Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 20/20 | 0.72 |
| ▸ | CLK4 | Q9HAZ1 | 19/20 | 0.72 |
| ▸ | DYRK1A | Q13627 | 18/20 | 0.72 |
| ▸ | DYRK2 | Q92630 | 18/20 | 0.72 |
| ▸ | DYRK1B | Q9Y463 | 18/20 | 0.72 |
| ▸ | CLK2 | P49760 | 16/20 | 0.72 |
| ▸ | DYRK3 | O43781 | 16/20 | 0.72 |
| ▸ | CLK3 | P49761 | 14/20 | 0.72 |
| ▸ | DYRK4 | Q9NR20 | 13/20 | 0.72 |
| ▸ | GSK3B | P49841 | 11/20 | 0.72 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.62 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.54 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.54 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PRKCB | P05771 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.53 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23970473 | 0.88 | CLK1 (0.72) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL25590037 | 0.87 | CLK1 (0.69) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL23510515 | 0.86 | DYRK2 (0.84) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL29899824 | 0.86 | DYRK2 (0.84) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL25590036 | 0.85 | CLK1 (0.66) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL23510450 | 0.84 | DYRK1A (1.00) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL29015886 | 0.84 | DYRK1A (1.00) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL29899879 | 0.84 | DYRK1A (1.00) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL23970295 | 0.84 | CLK1 (0.77) | CLK1CLK4DYRK1ADYRK2DYRK1B | |
| SCHEMBL23970190 | 0.84 | CLK1 (0.67) | CLK1CLK4DYRK1ADYRK2DYRK1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3904354-A1 | NEW IMIDAZOLONE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES IN PARTICULAR DYRK1A, CLK1 AND/OR CLK4 | Perha Pharmaceuticals (FR) | 2021-11-03 | — | — | EP | disclosed |