Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP30 | Q70CQ3 | 8/20 | 0.56 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | PBK | Q96KB5 | 1/20 | 0.46 |
| ▸ | CNR1 | P21554 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | ANO1 | Q5XXA6 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23970666 | 0.91 | USP30 (0.52) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL23970673 | 0.90 | USP30 (0.52) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL23970777 | 0.89 | USP30 (0.50) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL23971068 | 0.86 | USP30 (0.47) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL29778997 | 0.82 | USP30 (0.67) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL18124183 | 0.82 | USP30 (0.67) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL28513485 | 0.82 | USP30 (0.67) | USP30PARP1HDAC4HDAC6RIPK1 | |
| SCHEMBL12426360 | 0.82 | USP30 (0.52) | USP30PARP1HDAC4RIPK1SCN9A | |
| SCHEMBL19118949 | 0.82 | USP30 (0.57) | USP30PARP1HDAC4HDAC6PBK | |
| SCHEMBL19118950 | 0.82 | USP30 (0.57) | USP30PARP1HDAC4HDAC6PBK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222353-A1 | MACROCYCLIC INHIBITORS OF PEPTIDYLARGININE DEIMINASES | GILEAD SCIENCES, INC. (US) | 2021-11-04 | — | — | WO | disclosed |