Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 8/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MELK | Q14680 | 2/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane Carboxylic Acid SCHEMBL1557567 | 0.89 | CLK2 (0.48) | MTORDYRK1A | |
| SCHEMBL1558848 | 0.88 | MTOR (0.49) | MTORALDH1A1DYRK1ABRAFPIK3CD | |
| SCHEMBL2399435 | 0.86 | MTOR (0.45) | MTORDYRK1ABRAFPIK3CDPIK3CA | |
| SCHEMBL2397218 | 0.86 | MTOR (0.40) | MTORALDH1A1MELKPIK3CDPIK3CA | |
| SCHEMBL2394781 | 0.82 | MTOR (0.42) | MTORALDH1A1DYRK1APIK3CDPIK3CA | |
| SCHEMBL1559132 | 0.80 | MTOR (0.44) | MTORALDH1A1PIK3CDPIK3CA | |
| SCHEMBL2396069 | 0.80 | MTOR (0.52) | MTORALDH1A1USP30PIK3CDPIK3CA | |
| SCHEMBL2396700 | 0.79 | MTOR (0.51) | MTORALDH1A1PIK3CDPIK3CA | |
| SCHEMBL1558563 | 0.78 | PDPK1 (0.48) | MTORPIK3CDPIK3CA | |
| SCHEMBL2400646 | 0.78 | MTOR (0.44) | MTORALDH1A1DYRK1APIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PROGENICS PHARMACEUTICALS, INC. | 2011-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212053-A1 | PHOSPHATIDYLINOSITOL 3 KINASE INHIBITORS | PIK3CA, AKT1, PIK3R5 | MTOR 26/4885ALDH1A1 4549/4885MELK 687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.