Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 7/20 | 0.51 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.51 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.51 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.51 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.51 |
| ▸ | PRKDC | P78527 | 1/20 | 0.51 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.51 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12264883 | 0.89 | PIK3CA (0.40) | MTORPIK3CAPIK3R1PIK3CGPIK3R5 | |
| SCHEMBL12312702 | 0.86 | MTOR (0.55) | MTORPIK3CAPIK3R1PIK3CGPIK3R5 | |
| SCHEMBL2397720 | 0.83 | PIK3CA (0.47) | MTORPIK3CA | |
| SCHEMBL12831962 | 0.80 | PIK3CA (0.38) | MTORPIK3CA | |
| SCHEMBL2393329 | 0.76 | PIK3CA (0.46) | MTORPIK3CA | |
| SCHEMBL30984497 | 0.74 | PIK3CA (0.61) | MTORPIK3CAPIK3R1PIK3CGPIK3R5 | |
| SCHEMBL27428887 | 0.74 | PIK3CA (0.61) | MTORPIK3CAPIK3R1PIK3CGPIK3R5 | |
| SCHEMBL1310732 | 0.71 | MTOR (0.76) | MTORPIK3CAPIK3R1PIK3CGPIK3R5 | |
| SCHEMBL2399725 | 0.71 | PIK3CA (0.39) | MTORPIK3CAPIK3R1PIK3CB | |
| SCHEMBL1497342 | 0.71 | PIK3CA (0.50) | MTORPIK3CAPIK3R1PIK3CGPIK3R5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-09-22 | — | — | US | disclosed |
| WO-2011031896-A2 | PI3 KINASE INHIBITORS AND USES THEREOF | AVILA THERAPEUTICS, INC. (US) | 2011-03-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110230476-A1 | PI3 KINASE INHIBITORS AND USES THEREOF | PIK3CA, PIK3CB, PIK3C2B | MTOR 37/4885PIK3CA 1/4885PIK3R1 20/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.