Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MLNR | O43193 | 10/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | CCR3 | P51677 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378303 | 0.90 | MLNR (0.55) | MLNRGAAHRH3CCR1CCR5 | |
| SCHEMBL377587 | 0.88 | MLNR (0.43) | MLNRGPR119CCR1CCR5 | |
| SCHEMBL377747 | 0.86 | MLNR (0.54) | MLNRGPR119CCR3 | |
| SCHEMBL377769 | 0.83 | CCR1 (0.44) | MLNRCCR1CCR5 | |
| SCHEMBL3570118 | 0.82 | MLNR (0.60) | MLNRCCR1 | |
| SCHEMBL377408 | 0.82 | MLNR (0.76) | MLNR | |
| SCHEMBL3559459 | 0.82 | MLNR (0.69) | MLNRCCR1CCR5 | |
| SCHEMBL13404692 | 0.81 | MLNR (0.53) | MLNRCCR5 | |
| SCHEMBL13404693 | 0.80 | MLNR (0.66) | MLNRCCR1CCR5 | |
| SCHEMBL2766675 | 0.79 | MLNR (0.54) | MLNRCCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8012981-B2 | Benzylpiperazine derivatives as motilin receptor agonists | GLAXO GROUP LIMITED (GB) | 2011-09-06 | — | — | US | disclosed |