Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | METAP2 | P50579 | 1/20 | 0.32 |
| ▸ | METAP1 | P53582 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975799 | 0.90 | PDE10A (0.36) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23976662 | 0.88 | MEN1 (0.36) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23975832 | 0.84 | CFTR (0.39) | PDE10AKMT2ATDP1RAB9ACFTR | |
| SCHEMBL23976570 | 0.83 | PDE10A (0.40) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23975568 | 0.83 | PDE10A (0.40) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23975774 | 0.83 | PDE10A (0.40) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23975848 | 0.82 | PDE10A (0.39) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23975718 | 0.82 | PDE10A (0.39) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL23986923 | 0.82 | PDE10A (0.39) | PDE10ACYP1A2MEN1KMT2ATDP1 | |
| SCHEMBL30118660 | 0.82 | PDE10A (0.39) | PDE10ACYP1A2MEN1KMT2ATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021222483-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2021-11-04 | — | — | WO | disclosed |