Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.51 |
| ▸ | CDK9 | P50750 | 5/20 | 0.51 |
| ▸ | CDK1 | P06493 | 4/20 | 0.51 |
| ▸ | CCNB1 | P14635 | 4/20 | 0.51 |
| ▸ | CDK4 | P11802 | 4/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.51 |
| ▸ | CDK7 | P50613 | 3/20 | 0.51 |
| ▸ | CCNH | P51946 | 3/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.45 |
| ▸ | CCND1 | P24385 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.45 |
| ▸ | ABL2 | P42684 | 1/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | MNAT1 | P51948 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2395328 | 0.81 | KDR (0.49) | CDK2CDK4KMT2AABL1KDR | |
| SCHEMBL2399934 | 0.79 | MEN1 (0.53) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL2397191 | 0.79 | KDR (0.45) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL1888443 | 0.77 | NPC1 (0.48) | KMT2AKDRMAPTMEN1LMNA | |
| SCHEMBL48503 | 0.76 | MEN1 (0.65) | KMT2ACDK5CDK5R1POLBMAPT | |
| SCHEMBL1891863 | 0.76 | KDR (0.41) | KMT2AKDRMAPTMEN1LMNA | |
| SCHEMBL2396335 | 0.75 | PIK3CD (0.57) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL2397208 | 0.75 | PIK3CD (0.49) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL2395910 | 0.74 | MEN1 (0.60) | CDK2CCNT1CDK9CDK1CCNB1 | |
| SCHEMBL3598571 | 0.74 | MEN1 (0.52) | CDK2CCNT1CDK9CDK1CCNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8017608-B2 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2011-09-13 | — | — | US | disclosed |
| EP-1608647-B1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2008-01-09 | — | — | EP | disclosed |
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | NOVARTIS AG (CH) | 2006-07-06 | — | — | US | disclosed |
| EP-1608647-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | Novartis AG (CH) | 2005-12-28 | — | — | EP | disclosed |
| WO-2004078754-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND THEIR USE AS P13 KINASE INHIBITORS | NOVARTIS AG (CH) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148822-A1 | 5-Phenylthiazole derivatives and their use as p13 kinase inhibitors | MAP3K13, AKT3, MAP3K3 | CDK2 60/4885CCNT1 201/4885CDK9 190/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.